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Functional Genomics provides infrastructure for CRISPR-based gene editing and Target Discovery and Deconvolution services via high throughput screening, from initial feasibility assessment, all the way through to verification of identified targets. It also serves as repository for reagents and assays, expertise and other technical information, and works towards technical improvements when necessary.
The Core’s primary effort is dedicated to cell-based genetic screening, both loss of function (via RNAi, CRISPR-Cas9 screening) and gain of function (via ORF overexpression and CRISPRa screening). In addition it offers cell line engineering services to create cellular models for screening and/or target validation.
Our personnel develop both plate reader and image-based cellular assays, and adapt them to HTS screening conditions in conjunction with the High Content Screening Core. It also collaborates with the Bioinformatics, Proteomics and Sequencing Shared Resources to aid the screening follow-up process.
Services:
Cell-based Genetic Screening:
Cell line engineering.
Chun_Teng Huang | Acting Director
Hours | Location |
Monday through Friday 8AM to 5PM |
Bldg 2 -Room 2218 |
Name | Role | Phone | Location | |
---|---|---|---|---|
Chun-Teng Huang |
Director
|
858-646-3100 x4353
|
cthuang@SBPdiscovery.org
|
Bldg 7 -Room 7112
|
Pricing |
► Products and Services (3) | |||
Name | Description | Price | |
---|---|---|---|
CAS9 lines, base price |
cell lines expressing Cas9, constitutively or inducible by doxicyclin. base price applies to standard immortal lines, able to grow from single cells |
Inquire | |
CRISPR KI base price |
reporter insertions, tag insertions, sequence editing |
Inquire | |
CRISPR KO, base price | Inquire | ||
► Screening Services (5) | |||
Name | Description | Price | |
Hs. Epigenetics, pooled_screen | Inquire | ||
Hs. GPCRs, pooled_screen | Inquire | ||
Hs. phosphatases, pooled_screen | Inquire | ||
Hs. Ubiquinome pooled_screen | Inquire | ||
Hs. miRvana miRNA mimics_screen | Inquire |