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Assay Development/HTS (Lake Nona)

Overview of Services

The high-throughput screening (HTS) assay development team provides support for the design and development of new HTS assays as well as optimization support for existing assays. The assay development team, as well as the HTS team are skilled in most screening modalities, to help with selection and development of assays most suitable to each particular project. The team also provides support in the design of optimal structure-activity relationship (SAR) panels, development of supporting assays, data analysis, and interpretation for studies aimed at characterization and optimization of hits obtained in primary HTS.

The high-throughput screening facility offers the necessary infrastructure for scientists conducting chemical library screening of biological targets. The facility provides diverse screening instrumentation, compound libraries, and expertise in high-throughput screens and automation. The facility supports both user- and facility-driven screening projects. In conjunction with the assay development facilities in Lake Nona and La Jolla, as well as the high-content screening facility, it works to help select and implement the most suitable biochemical or cellular assays for each project.

The facilities are part of Conrad Prebys Center for Chemical Genomics and can advise and help in preparation of data packages for screening-related grants.

Leadership

Siobhan Malany, Ph.D. | Assay Development

 

Steve Vasile, Ph.D. | High Throughput Screening

Location and hours of operation

Location  

Orlando, FL


Links and Resources

  1. Assay Development Facility
  2. ultra-High Throughput Screening Facility
  3. Compound Libraries
  4. Instrumentation

Contacts

Name Role Phone Email Location
Siobhan Malany
Chem Bio Team Leader
 
407-745-2000 x2579
 
smalany@sanfordburnham.org
 
Orlando, FL
 
Steve Vasile
Director - HTS
 
407-745-2095
 
svasile@sanfordburnham.org
 
Orlando, FL